Dr. Adel Nefzi
Torrey Pines Institute
BiographyDr. Nefzi obtained his Ph.D. in Chemistry in 1995 from the University of Lausanne in Switzerland. Dr. Nefzi is currently a full member and director of chemistry at Torrey Pines Institute for Molecular Studies (TPIMS) in Port Saint Lucie, Florida, working in the design and the synthesis of small molecules and heterocyclic combinatorial libraries and their application in drug discovery (www.tpims.org). He has more than 130 publications in many outstanding journals, numerous lectures at scientific symposia and nine issued US patents. Dr. Nefzi obtained many grant rewards from NIH and NSF for his research in Combinatorial Chemistry and Drug Discovery. He is also, an adjunct professor at Florida Atlantic University. Between 2002 and 2008, Dr. Nefzi taught organic chemistry at the upper division of Organic Chemistry at the University of California San Diego (UCSD). Dr. Nefzi is a member of American Chemical Society, member of American Peptide Society, member of American Association of Pharmaceutical Scientists and member of Fluorine Chemistry Society. In addition, Dr. Nefzi is an executive member of The Society for the Advancement of Science and Technology in the Arab World (SASTA) (http://www.sastaworld.com/).
Combinatorial Chemistry and Drug DiscoveryThe last two decades has witnessed major breakthroughs in the identification of genes, gene products, metabolic pathways, and signaling pathways, as well as progress in miniaturization and robotics, enabling the development of high-throughput mechanism-based biological assays. One of the central objectives of organic and medicinal chemistry is the design, synthesis, and production of molecules having value as human therapeutic agents. Our research group is interested in the design, synthesis, analysis, conformations, dynamics and structure-biological activity relationships of diverse nitrogen heterocycles of different ring sizes. Diaza- and triaza-cyclic compounds with different substitution patterns and embedded in various molecular frameworks constitute important structure classes in the search for bioactivity. The compounds are designed to follow known drug-likeness rules including “Lipinski’s Rule of Five”. Examples of the identification of highly active compounds from mixture based libraries will be presented.